《英文msh詞典》Allergic Neuritis,Experimental
[同義詞] Allergic Neuritis,Experimental
[主題詞] Neuritis,Experimental Allergic
[中文釋義] 過敏性神經(jīng)炎,實驗性
[英文釋義] An experimental animal demyelinating disease model of GUILLAINE-BARRE SYNDROME. In the most frequently used protocol,animals are injected with a peripheral nerve tissue protein homogenate. After approximately 2 weeks the animals develop a neuropathy secondary to a T cell-mediated autoimmune response directed towards the MYELIN P2 PROTEIN in peripheral nerves. Pathologic findings include a perivascular accumulation of macrophages and T lymphocytes in the peripheral nervous system,similar to that seen in the Guillaine-Barre syndrome. (From Adams et al.,Principles of Neurology,6th ed,p1314; J Neuroimmunol 1998 Apr 1;84(1):40-52)